Preventing Epilepsy Deaths: Clinician Toolkit


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Jones JE, Hermann BP, Barry JJ, Gilliam FG, Kanner AM, Meador KJ. Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy. Epilepsy & Behavior. 2003;4:31-38. doi:10.1016/j.yebeh.2003.08.019


Kanner AM. Management of psychiatric and neurological comorbidities in epilepsy. Nature Reviews Neurology. 2016;12(2):106-116. doi:10.1038/nrneurol.2015.243


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Mbizvo GK, Bennett K, Simpson CR, Duncan SE, Chin RFM. Epilepsy-related and other causes of mortality in people with epilepsy: A systematic review of systematic reviews. Epilepsy Research. 2019;157:106192. doi:10.1016/j.eplepsyres.2019.106192


McKnight D, Bristow SL, Truty RM, et al. Multigene Panel Testing in a Large Cohort of Adults With Epilepsy. Neurology Genetics. 2021;8(1):e650. doi:10.1212/nxg.0000000000000650


Miller W, Rollnick S. Motivational Interviewing: Preparing People for Change, 2nd ed. Journal For Healthcare Quality. 2003;25(3):46. doi:10.1097/01445442-200305000-00013


Nascimento FA, Tseng ZH, Palmiere C, et al. Pulmonary and cardiac pathology in sudden unexpected death in epilepsy (SUDEP). Epilepsy & Behavior. 2017;73:119-125. doi:10.1016/j.yebeh.2017.05.013


Neligan A, Noyce AJ, Gosavi TD, Shorvon SD, Köhler S, Walker MC. Change in Mortality of Generalized Convulsive Status Epilepticus in High-Income Countries Over Time. JAMA Neurology. 2019;76(8):897. doi:10.1001/jamaneurol.2019.1268


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Nogueira MH, Yasuda CL, Coan AC, Kanner AM, Cendes F. Concurrent mood and anxiety disorders are associated with pharmacoresistant seizures in patients with MTLE. Epilepsia. 2017;58(7):1268-1276. doi:10.1111/epi.13781


Penovich P, Glauser T, Becker D, et al. Recommendations for development of acute seizure action plans (ASAPs) from an expert panel. Epilepsy & Behavior. 2021;123:108264. doi:10.1016/j.yebeh.2021.108264


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Position Statement on SUDEP Counseling. AES. Accessed August 11, 2022.


Rugg-Gunn F. The role of devices in managing risk. Epilepsy & Behavior. 2020;103:106456. doi:10.1016/j.yebeh.2019.106456


Ryu HU, Hong JP, Han S-H, et al. Seizure Frequencies and Number of Anti-epileptic Drugs as Risk Factors for Sudden Unexpected Death in Epilepsy. Journal of Korean Medical Science. 2015;30(6):788. doi:10.3346/jkms.2015.30.6.788


Selim M, Anilkumar AC, Cichowski E. Antiepileptic Drug Monitoring. NCBI Bookshelf. Published June 23, 2022. Accessed November 30, 2022.


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Strzelczyk A, Griebel C, Lux W, Rosenow F, Reese J-P. The Burden of Severely Drug-Refractory Epilepsy: A Comparative Longitudinal Evaluation of Mortality, Morbidity, Resource Use, and Cost Using German Health Insurance Data. Frontiers in Neurology. 2017;8. doi:10.3389/fneur.2017.00712


Sun JJ, Perera B, Henley W, et al. Epilepsy related multimorbidity, polypharmacy and risks in adults with intellectual disabilities: a national study. Journal of Neurology. 2022;269(5):2750-2760. doi:10.1007/s00415-021-10938-3


Sutton F, Barca D, Komoltsev I, et al. Testing blood and CSF in people with epilepsy: a practical guide. Epileptic Disorders. 2020;22(4):381-398. doi:10.1684/epd.2020.1191


Sveinsson O, Andersson T, Carlsson S, Tomson T. Circumstances of SUDEP: A nationwide population‐based case series. Epilepsia. 2018;59(5):1074-1082. doi:10.1111/epi.14079


Sveinsson O, Andersson T, Mattsson P, Carlsson S, Tomson T. Clinical risk factors in SUDEP: A nationwide population-based case-control study. Neurology. 2020;94(4). doi:10.1212/WNL.0000000000008741
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Szczurkowska PJ, Polonis K, Becari C, Hoffmann M, Narkiewicz K, Chrostowska M. Epilepsy and hypertension: The possible link for sudden unexpected death in epilepsy? Cardiology Journal. 2021;28(2):330-335. doi:10.5603/cj.a2019.0095


Tarighati Rasekhi R, Devlin KN, Mass JA, et al. Improving prediction of sudden unexpected death in epilepsy: From SUDEP‐7 to SUDEP‐3. Epilepsia. 2021;62(7):1536-1545. doi:10.1111/epi.16928


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Wells J, Swaminathan A, Paseka J, Hanson C. Efficacy and Safety of a Ketogenic Diet in Children and Adolescents with Refractory Epilepsy—A Review. Nutrients. 2020;12(6). doi:10.3390/nu12061809


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Young C, Shankar R, Palmer J, et al. Does intellectual disability increase sudden unexpected death in epilepsy (SUDEP) risk? Seizure. 2015;25:112-116. doi:10.1016/j.seizure.2014.10.001